Kammuri turning to super typhoon less likely but possible — Pagasa Read Next Fire hits houses in Mandaluyong City “And it’s not anything personal, I’m not here to tirade anybody, I’m not here to go at any particular person or the organization, because I have nothing but love for Cleveland. I have nothing but love for the times that I spent there. It’s nothing about that.”After mostly keeping to himself since the trade went down, Irving further explained his motivations behind leaving Cleveland.“It’s just there comes a time when you mature as an individual. It’s time to make that decision,” he shared.“And there is no looking back from that standpoint. There is no time to figure out how to save someone’s feelings, when ultimately you have to be selfish in figuring out what you want to do. And it wasn’t about me not wanting to win. It wasn’t anything about that. I want to be extremely, extremely happy in perfecting my craft. And that was the only intent that I have in all of this.” Khristian Ibarrola /raADVERTISEMENT Nonong Araneta re-elected as PFF president LATEST STORIES Frontrow holds fun run to raise funds for young cancer patients LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Don’t miss out on the latest news and information. Appearing on ESPN’s “First Take,” the 25-year-old guard confirmed that he did not speak with LeBron about his trade request, nor did he feel obligated to do so.“Did you speak to LeBron James or talk to LeBron James before you and your representatives met with ownership before you let them know you wanted out?” host Stephen A. Smith candidly asked the four-time All-Star.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“No. Why would I have to?” Irving responded, prompting Smith to say that LeBron might have taken it personally.Without mentioning his former teammate’s name, Irving calmly explained his side: “I don’t think you owe anything to another person in terms of figuring out what you want to do with your life.” E.T. returns to earth, reunites with grown-up Elliott in new ad Brace for potentially devastating typhoon approaching PH – NDRRMC Trending Articles PLAY LIST 00:50Trending Articles03:46Lacson: PH lost about P161.5B tax revenue from big trading partners in 201700:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games MOST READ Austin, Ravena lead PH team in 2017 FIBA Asia Champions Cup Former teammates Kyrie Irving (left) and LeBron James AFP/GETTY IMAGES FILE PHOTOKyrie Irving and LeBron James will share the court on opening night of the 2017-2018 NBA regular season next month. But for the first time in a long time, it won’t be as teammates.Irving recently demanded his way out of the Cleveland Cavaliers and got his wish when he was traded to the Boston Celtics.ADVERTISEMENT View comments
Man City midfielder Bernardo Silva: Gabriel Jesus goals will do him goodby Paul Vegas10 months agoSend to a friendShare the loveManchester City midfielder Bernardo Silva was pleased for Gabriel Jesus after his two goals in victory over Everton.The opener marked the striker’s first Premier League goal since August.”It was good after the defeat against Chelsea to give an answer,” Bernardo explained. “It was not an easy game.”To have difficult games against Hoffenheim and Everton, it was good to come back from that.”The next two months are hard, we need to be focused and fit, get as many wins as can to recover first position and go as far as we can in other competitions.””We are happy with Jesus’ two goals and hopefully he can score more and win more titles.” About the authorPaul VegasShare the loveHave your say
TagsTransfersAbout the authorPaul VegasShare the loveHave your say Norwich midfielder Alex Tettey shuts down Rosenborg talkby Paul Vegasa month agoSend to a friendShare the loveAlexander Tettey insists he’s happy where he is at Norwich City.The midfielder, 33, is consistently being linked with a return to Norway at Rosenborg.But he told VG: “It is important that what is written is true, and that it is not portrayed that I’m hunting anything. “I’m not chasing a contract with Rosenborg, I’m not chasing to portray it as ‘I’ll be back, make room for me’. Absolutely not.”Tettey added: “I love Rosenborg, they mean a lot to me, but I don’t want to go to Rosenborg as a 34-year-old who everyone just wants to remember how he was before. It gives me nothing, it gives the club nothing, it gives the fans nothing.”
Writing about dress colors isn’t usually in our wheelhouse, but given how the sports world was responding to the viral debate regarding this photo Thursday night, we figured we’d get involved. We also figured we’d update you on the answer to the debate, as well as the reason that people are seeing the same dress in such drastically different colors.First, for those who haven’t seen the photo before – see below. Some people see it as white and gold, while others see it as blue and black.In the morning when I was looking at that dress, it was black&blue now in the evening its white&gold! WTF? HOW? :DDD pic.twitter.com/lwS8oQlcvx— Laura Slivka (@zeGoattt) February 27, 2015In reality, the dress is blue and black. That will probably shock half of you out there, but it’s true.Hey everyone, you can buy the dress yourself and see that it’s blue and black #whiteandgold #blackandblue #yallidiots pic.twitter.com/7XkMgMPFvi— Max (@thabaerjew) February 27, 2015So why is the world split on this? Wired probably has the best explanation we’ve seen out there. In short, a given person’s visual system is either discounting the color blue or the color gold involuntarily.This image, though, hits some kind of perceptual boundary. That might be because of how people are wired. Human beings evolved to see in daylight, but daylight changes color. That chromatic axis varies from the pinkish red of dawn, up through the blue-white of noontime, and then back down to reddish twilight. “What’s happening here is your visual system is looking at this thing, and you’re trying to discount the chromatic bias of the daylight axis,” says Bevil Conway, a neuroscientist who studies color and vision at Wellesley College. “So people either discount the blue side, in which case they end up seeing white and gold, or discount the gold side, in which case they end up with blue and black.” (Conway sees blue and orange, somehow.)Business Insider also has a decent writeup on the situation.The sports world has been having a field day relating this to team colors. Coach Cal made a joke last night. Duke basketball made another this morning. It probably won’t end for some time.
Reviewed by James Ives, M.Psych. (Editor)Oct 30 2018Immunotherapy — harnessing T-cells to attack cancer cells in the body — has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy still benefits only a minority of patients — a reality driving research in the field for ways to improve the relatively new approach.One method for improving efficacy is the development of bio- and activity-based markers to better predict which patients will respond to immunotherapy and identify why some don’t. In a new study in the Proceedings of the National Academy of Sciences, researchers at the University of Notre Dame studying tumors in prostate cancer models found that nitration of an amino acid can inhibit T-cell activation, thwarting the T-cell’s ability to kill cancer cells.”People put a lot of hope on immunotherapy, and it has worked well for some patients, but overall the number is still low,” said Xin Lu, John M. and Mary Jo Boler Assistant Professor of Biological Sciences at Notre Dame who studies molecular understanding and immunotherapy of metastatic cancer. “By identifying activity-based markers like this one, we can design approaches that shut down the particular mechanisms that inhibit T-cell activation so immunotherapy can work.”In the study, Lu and his team explain how highly reactive molecules, called reactive nitrogen species (RNS), produced by myeloid-derived suppressor cells (MDSCs) cause nitration of an amino acid in a lymphocyte-specific protein called tyrosine kinase (LCK), which is crucial for T-cell activation. Nitration is a process to add a special chemical group “nitro” to the amino acid molecule, called tyrosine, in proteins. After this modification, the protein may alter its overall structure thus exhibiting different functions. MDSCs are prevalent in solid tumors that contribute to more than 90 percent of all cancers.Prostate cancer “is a slow progressing disease,” Lu said. “Nevertheless, for patients with aggressive cases of prostate cancer, there is no effective treatment.”Related StoriesNew protein target for deadly ovarian cancerResearchers identify potential drug target for multiple cancer typesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerAccording to the American Cancer Society, prostate cancer is the second leading cause of cancer-related death for men in the United States behind lung cancer. Lu and his team also looked at tumors in lung cancer models, and tested treatments as part of the study.”At this moment, we don’t have an agent to block a particular amino acid from nitration,” Lu said. “But we do have ways to block nitration all together.”Lu tested three methods of treatment to block nitration, which would keep the LCK protein active — and allow it to do its job of killing cancer cells. Treating models with an immune checkpoint blockade or uric acid, which can neutralize RNS to limited degrees, yielded little response in the tumor models.”When we combined them, our results showed that it could suppress RNS, activate cytotoxic T cells and achieve impressive efficacy,” Lu said.While MDSCs are highly abundant in solid tumors, they are not all alike, which is why Lu is focusing on activity taking place at the molecular level. The hope is to expand the study and investigate new antibodies capable of recognizing this particular type of modification for better prognosis.”You can imagine in the clinic, if a patient comes in with metastatic prostate cancer from which a fine-needle biopsy can be acquired, you can look for MDSC activity using the nitrated protein biomarker and predict whether or not an agent that inhibits MDSC will be required for immunotherapy to work,” he said.Because MDSCs are in high abundance in many types of solid tumors, Lu said it could be argued that the phenomenon found in the prostate cancer models has a high likelihood of applying to other solid tumors in other types of cancer.”The question is how we reach more people,” Lu said. “The goal is to identify biomarkers and therapeutic targets that enhance current immunotherapies to unleash more power from these therapies. By doing this, we may benefit many more patients.” Source:https://news.nd.edu/news/scientists-neutralize-reactive-nitrogen-molecules-to-enhance-cancer-immunotherapy/
Source:https://www.nationwidechildrens.org/ Reviewed by James Ives, M.Psych. (Editor)Nov 5 2018Millions of children and teens are affected by sports and recreation-related traumatic brain injuries (TBI) annually. To help reduce the effects of TBIs in youth sports, all 50 states and the District of Columbia enacted state youth TBI laws between 2009 and 2014. A new study from researchers in the Center for Injury Research and Policy at Nationwide Children’s Hospital examined the effectiveness of these laws by looking at sports and recreation mild TBI (mTBI)-related emergency department (ED) visits for children ages 5 to 18 years before and after TBI legislation was enacted in each state. Specifically, researchers looked at ED visits from 2006 through 2014 for diagnosis of mTBI and compared them with diagnoses of moderate to severe TBI, minor head injury, and long bone fracture.The study, published online today in Journal of Head Trauma and Rehabilitation, found that when youth TBI legislation is enacted, utilization of the ED for youth sports and recreation-related mTBI evaluations increase. “This is what we want to see,” said Ginger Yang, PhD, MPH, senior author of the study and principal investigator in the Center for Injury Research and Policy at Nationwide Children’s. “An increase in ED visits for youth sports TBIs shows the laws are working – more children are getting evaluated by a healthcare professional, which is one of the key tenets of youth TBI laws.” The laws also contribute to an increased awareness of youth TBIs, which may prompt many athletes, parents, trainers, and coaches to seek out evaluation for a suspected or actual TBI.Related StoriesNew network for children and youth with special health care needs seeks to improve systems of careRush University Medical Center offers new FDA-approved treatment for brain aneurysmsAn active brain and body associated with reduced risk of dementiaED visits for mTBIs were more common among boys (67.5%), children ages 10-14 years (42.1%), and the privately insured (50.6%). The proportion of mTBI ED visits increased significantly, particularly from 5 years pre-legislation to immediately post-legislation (57.8 to 94.8 mTBI visits per 10,000 ED visits). A similar trend was observed for minor head injuries; however, no significant changes were observed for moderate to severe TBIs and long bone fractures.”Due to the unprecedented, rapid passing of youth state TBI legislations, EDs may not have received the necessary information, time, and resources to prepare for the large influx of mTBI visits during and/or after legislation,” said Julie Leonard, MD, MPH, associate director of the Center for Pediatric Trauma Research, principal investigator in the Center for Injury Research and Policy, and co-author of this study. “EDs can help remedy this by allocating appropriate time and resources for mTBIs.”For example, specific materials can be developed as resources for families, and efforts can be made to educate staff about mTBI. Further, communication channels can be established between the ED and other providers (e.g., sports medicine, primary care) to more easily facilitate follow-up care for patients. All healthcare providers should develop a proactive plan when public health mandates result in increased utilization, and policy makers should consider the potential impact of hospitals and patients when developing and enacting future legislation.
Reviewed by James Ives, M.Psych. (Editor)Dec 24 2018Multi-Walled Carbon Nanotubes (MWCNTs) are characterized by walls formed by a one atom thick sheet of carbon. Using MWCNTs as a drug delivery system, the requirement for the solvent and drug dissolution in a solution can be avoided. Soyasapogenol B (SSB) is a product derived from soya bean that belongs to the family of oleanane triterpenes. It is also known to have biological functions in cell signaling, membrane integrity and stability and energy storage. Soyasapogenol B may demonstrate hypo-cholesterolemic effects. Soyasapogenol B happens to be an important therapeutic agent due to its many biological activities. SSB can be loaded with MWCNTs with tetraethyl orthosilicate (TEOS) and/or chitosan.Related StoriesNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Olympus Europe and Cytosurge join hands to accelerate drug development, single cell researchScreenIn3D receives technology innovation prizeBy using miniemulsion techniques, SBB was immobilized onto MWCNTs. Additionally, niosomes were used to enclose the prepared systems. The analysis of the particle systems was done by Fourier Transform Infrared Spectroscopy (FTIS), Transmission Electron Microscopy (TEM), and size distribution analysis. Kinematics of the release of the particles and SBB particles that had an in vitro release profiles, were carried out. In vitro cytotoxicity of synthesized materials was analyzed and was examined by using cell lines such as normal melanocytes (HFB4), liver and carcinoma breast by the comparison with standard doxorubicin.The results of the experiment revealed that SSB loaded materials were able to display controlled and sustained drug release, which also obeyed mathematical in vitro profiles in line with multiple models. The preparations were also minimally cytotoxic in all cell lines tested.The research demonstrates the use of loading a bioactive agent such as SSB into MWCNTs to deliver it into multiple cell types with minimal toxicity. This is useful information for reasearchers looking into new drug delivery technologies for therapeutics.Source: https://benthamscience.com/
Facebook and Google are mapping big expansions in Chicago, where real estate searches by two of the nation’s other technology giants have been the center of attention. Citation: Tech behemoths Facebook, Google planning big Chicago office expansions (2018, June 6) retrieved 18 July 2019 from https://phys.org/news/2018-06-tech-behemoths-facebook-google-big.html A Facebook spokeswoman and John Buck President and Chief Investment Officer Kevin Hites did not respond to requests for comment.In May, Crain’s Chicago Business reported that Facebook has been poaching recruiters from other Chicago companies so the social media company can make hundreds of new hires in the city.The Franklin Street space would be large enough to accommodate more than 1,000 employees.Facebook is represented by brokers at Cushman & Wakefield. John Buck is represented by Bill Rolander and Jon Cordell of Newmark Knight Frank.Google is expanding in Fulton Market, an area that it helped elevate a few years ago when it moved into 358,000 square feet in the former Fulton Market Cold Storage building, which was redeveloped by Chicago’s Sterling Bay and renamed 1KFulton.Google, which has nowhere else to expand at 1000 W. Fulton Market, is leasing 14,000 square feet on the ground floor that once had been planned as retail space for the building, Google spokeswoman Kayla Conti confirmed. She said that space will be used for Google’s salespeople to interact with clients.Just south of 1KFulton, Google is negotiating to take more than 100,000 square feet in a 12-story building Sterling Bay plans to finish building at 210 N. Carpenter St. by late this year, sources said.Sterling Bay managing principal Andy Gloor could not be reached for comment.Conti declined to comment on the Carpenter Street lease, or to say whether Google plans further expansion in the neighborhood. She said the Mountain View, Calif.-based company has more than 900 employees in Chicago.Google is represented by Kyle Kamin and Cal Wessman of CBRE. Sterling Bay and 1KFulton owner American Realty Advisors are represented by Sterling Bay leasing director Michael Lirtzman.About 60,000 of the Carpenter Street building’s 205,000 square feet already has been leased. Menlo Park, Calif.-based Facebook is negotiating to lease more than 200,000 square feet in a recently constructed office tower at 151 N. Franklin St. in the Loop, according to sources.Meanwhile, sources said, Google plans to add more than 100,000 square feet of office space in the city’s Fulton Market district, where the company already has a large Midwest headquarters.Those companies’ growth in Chicago comes as city and state officials await Amazon’s decision on its planned second headquarters, or HQ2. The Seattle-based company last year announced plans to pick a North American location to add up to 50,000 high-paying jobs, and Chicago in January learned it was among 20 locations still under consideration.Also in January, Mayor Rahm Emanuel said Chicago would try to lure Apple, which is seeking a new campus that would create more than 20,000 jobs. Cupertino, Calif.-based Apple has remained tight-lipped about potential locations for the campus, and it’s unclear whether Chicago is under consideration.For now, at least, Google and Facebook are the tech behemoths beefing up their presence in Chicago. Many of those companies’ existing employees are in sales.If the Facebook lease is completed as expected, it would cap a spring to remember for Chicago developer John Buck Co. In May, Facebook signed the largest office lease in San Francisco history, agreeing to fill all of a new, 756,000-square-foot tower developed by John Buck and two partners: Chicago-based Golub & Co. and the asset management arm of MetLife.How do Amazon HQ2 contenders measure up? We checked the data.The Chicago deal comes immediately after tenants began moving into John Buck’s 35-story tower at 151 N. Franklin St., where CNA Financial is the namesake tenant. Another tenant in the approximately 807,000-square-foot building is law firm Hinshaw & Culbertson.The largest block of remaining space is the top 10 floors, which have just over 257,000 square feet combined. It’s possible Facebook could fill all of that space.It’s unclear whether Facebook also plans to remain in a recently expanded office on Wacker Drive, or whether the spaces will be consolidated on Franklin Street. In October, the Tribune reported Facebook had expanded its space at 191 N. Wacker Drive to more than 100,000 square feet. Explore further Apple’s new flagship Chicago store is for sale, and could fetch $170 million or more ©2018 Chicago Tribune Distributed by Tribune Content Agency, LLC. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Voss reportedly met with Blues officials on Wednesday, Carlton’s first major move in their search for a new coach following Brendon Bolton’s sacking. Meanwhile, Carlton players, who have won three of their five games under David Teague, have reportedly lobbied the club to hire the caretaker coach in a full-time capacity.Teague was thought to be out of the running following comments Chris Judd made, though the football director has since clarified that no one is out of contention.Morris reports that Teague will be interviewed for the role nearer the end of the season. Port Adelaide assistant coach Michael Voss has emerged as a leading candidate for the vacant Carlton head coaching job. Speaking on Fox Sports on Wednesday, journalist Tom Morris said the 44-year-old met with club powerbrokers Cain Liddle, Brad Lloyd, Chris Judd and David Campbell to discuss the role.MORE: Two St Kilda greats call for the club to go after Luke Beveridge”Michael Voss has met with Carlton to be the club’s next senior coach,” Morris said.”He missed training at Port Adelaide (on Wednesday)… Carlton clearly like what he does, they like his coaching, he’s one of the front-runners for that role.”(Port Adelaide coach) Ken Hinkley has given Michael Voss his blessing to be (Carlton’s) next coach.”Voss has been out of a senior coaching job since he was sacked by Brisbane in 2013 after 43 wins in 109 games over a four-year stint.The Brownlow Medal winner and three-time premiership captain has since admitted that he wasn’t ready for a head coaching position when he took over in 2009.Voss got back on the horse as an assistant with Port in 2014 and has reportedly impressed with his development.He took charge of the midfield for several seasons before stepping up as Hinkley’s senior assistant in 2019.